![]() This strongly suggests that the underlying physics of propagation of sound and nerve impulses is indeed one and the same.Over the past decade, Li-ESWT (Low-intensity Extracorporeal Shockwave Therapy) has emerged as a controversial treatment modality for erectile dysfunction (ED). We have demonstrated a unique acoustic phenomenon that combines all the observable characteristics that define the propagation of nerve impulses. With the observation of annihilation of colliding sound pulses in the model lipid system, we have shown that qualitative characteristics of the entire phenomena of nerve pulse propagation can be derived solely from the principles of condensed matter physics and thermodynamics without the need for molecular models or fit parameters of the electrical theory. Even nonlinear sound pulses, such as solitons, typically remain unaffected upon collision, which was a major criticism of the proposed acoustic theory of nerve pulse propagation. The amplitudes of two sound pulses colliding head-on typically superimpose linearly before passing each other unaffected. Even from a purely acoustic physics perspective, this is a remarkable finding. Now, in research published in the Journal of Royal Society Interface, we have shown that these waves can even annihilate each other upon collision, just like nerve impulses. Thus only when sufficient energy is provided to cause a phase change in the lipids (fluid to gel-like), the entire pulse propagates otherwise nothing propagates, the so-called all-or-none propagation. These characteristics were shown to be a consequence of the conformational change or a phase transition in the lipid molecules that accompany the sound wave. Remarkably, even in such a minimalistic system that is devoid of any proteins and macromolecules other than lipids, these waves behave strikingly similar to nerve impulses in a neuron, including the solitary electromechanical pulse propagation, the velocity of propagation and all-or-none excitation. We showed that sound or compression waves can indeed propagate within a molecular thin film of lipid molecules, mimicking action potentials in the plasma membrane. Therefore, experimental evidence for such a phenomenon was crucial, which was provided by us in 2014. Moreover, sound waves are generally not associated with such characteristics, rather sound waves are known to spread out, disperse, dissipate, superimpose and interfere, which is counter-intuitive given the properties of nerve impulses. As a wave phenomenon, nerve pulse propagation has remarkable properties, such as a threshold for excitation, non-dispersive (solitary) and all-or-none propagation, and annihilation of two pulses that undergo head-on collision. The suggestion has been highly controversial because of the well-accepted and widely successful nature of the electrical basis of nerve pulse propagation in spite of its few inconsistencies. Thus the characteristics of the wave are derived from the principles of condensed matter physics and thermodynamics, unlike the emphasis on molecular biology in the electrical theory. In this framework, the electromechanical nature of the nerve impulse, also known as an action potential, emerges naturally from the collective properties of the plasma membrane, in which the sound or the compression wave propagates. To address these inconsistencies, researchers had previously proposed that nerve pulse propagation results from the same fundamental principles that cause the propagation of sound in a material and not the flow of ions or current. Furthermore, several studies have reported reversible temperature changes that accompany a nerve impulse, which is inconsistent with the electrical understanding from a thermodynamic standpoint. However, for as long as the electrical theory has been around, scientists have also been measuring various other physical signals that are equally characteristic of a nerve impulse, such as changes in the mechanical and optical properties that propagate in sync with the electrical signal. Nerve impulses are believed to propagate in a manner similar to the conduction of current in an electrical cable. The findings, published in the Journal of Royal Society Interface, provide the experimental evidence that sound waves propagating in artificial lipid systems that mimic the neuron membrane can annihilate each other upon collision – a remarkable property of signals propagating in neurons that was considered to be inaccessible to an acoustic phenomenon. The research was conducted in partnership with Professor Matthias F Schneider at the Technical University in Dortmund, Germany. Shamit Shrivastava, a post-doctoral researcher in the Department of Engineering Science, writes about a recent finding that has far-reaching consequences for the fundamental understanding of the physics of the brain. ![]()
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